The shikimate pathway is fundamental for the biosynthesis of aromatic amino acids—tryptophan, tyrosine and phenylalanine—in plants, bacteria and fungi. This pathway, which is absent in mammals, has ...

Enzymes in multistep metabolic pathways utilize an array of regulatory mechanisms to maintain a delicate homeostasis [K. Magnuson, S. Jackowski, C. O. Rock, J. E. Cronan, Jr, Microbiol. Rev. 57, ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

Yale scientists have taken a novel approach to unraveling the complex structure and regulation of enzymes: They Googled it. In a new study published online this week in the Proceedings of the National ...

Researchers at Yale say they used Google to help unravel the complex structure and regulation of enzymes. In a new study, “Eigenvector centrality for characterization of protein allosteric pathways,” ...

Chemistry professors used the Google algorithm PageRank to identify key amino acids in the regulation of a bacterial enzyme essential for most microorganisms. Yale scientists have taken a novel ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 74, No. 7 (Jul., 1977), pp. 2766-2770 (5 pages) Escherichia coli glutamine synthetase and glycogen phosphorylase ...

In a recent study posted to the bioRxiv* pre-print server, researchers investigated allosteric binders of angiotensin-converting enzyme 2 (ACE2) that significantly inhibit severe acute respiratory ...