A single treatment of viral vector-delivered CAR-A construct in mice with existing plaque saturation cut the amount of amyloid plaques in half.

Scientists have developed a promising new approach to treating Alzheimer’s disease by turning ordinary brain cells into powerful plaque-clearing machines. Instead of requiring frequent antibody ...

A new kind of cellular immunotherapy shows promise in preventing Alzheimer's-associated plaques from forming in the brain – ...

When we learn a new motor skill-whether mastering a piano passage or refining balance while walking-the brain must reorganize the circuits that ...

The Alzheimer's disease pathological cascade unfolds in the brain over decades, amidst a menagerie of cell types reacting to change. How, and when, does each cell type contribute to the process? A ...

Astrocytes use the MEGF10 receptor to prune synapses in the striatum, a process essential for dopamine-driven motor learning.

A research team has identified different subtypes of white matter (WM) astrocytes, including a unique type with the ability to multiply and potentially aid in brain repair. Using single-cell RNA ...

Increased expression of the Ang‐II (Angiotensin II) precursor AGT in aged astrocytes lead to increased Ang‐II signaling from aged astrocytes to endothelium, thus increasingblood–brain barrier (BBB) ...

Astrocytes in the cerebellum trigger a shift in GABA signaling during late adolescence, enabling adult-level motor coordination.

The new generation of Alzheimer's disease drugs—the first proven to change the course of the disease—typically extend independent living for patients by 10 months. Called monoclonal antibodies, they ...