A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein.

A new study published in Nature Genetics reveals that not all cancer-associated mutations in the same gene behave alike. Led ...

Cancer cells carry thousands of mutations, but not all mutations are created equal. Some make tumors highly visible to the ...

In mantle cell lymphoma (MCL), an aggressive form of B-cell non-Hodgkin lymphoma, TP53 mutations are known to affect patients’ prognosis—but questions remain. What does the heterogeneity of TP53 ...

Believed to be caused by a mix of genetic and environmental factors, Parkinson’s disease is a chronic, progressive disease that affects the central nervous system, particularly the motor system, ...

A new proof-of-concept method reliably engineered a hotspot mutation of SF3B1, a gene-splicing gene, into diverse cancer cell lines, outperforming other contemporary editing approaches. Oncogenesis ...

Study results indicate that mutation strength may shape both tumor–immune system interactions and immunotherapy response.

Genetic mutations aren't always a bad thing. A groundbreaking new study suggests that mutations on a single gene may actually be beneficial when it comes to Alzheimer’s disease. For the study, Dr.

Researchers say the deep learning model may help to create leads for new cancer diagnostics, patient stratification, and future therapies.

Flinders University researchers have discovered a rare genetic mutation that could explain why some people do not respond to ...

A study led by Aaron Hobbs, Ph.D., and Rachel Burge, Ph.D., at MUSC Hollings Cancer Center, reveals why a specific gene mutation behaves differently from other variants.