Clinical trials are losing participants. Patient-first design and decentralized models can help fix the dropout problem.

Real-world data is increasingly used to optimize trial design, reduce recruitment burden, and support regulatory decisions, but adoption remains uneven due to challenges around data quality, ...

“Well, we don’t have as much evidence as we would like on steroid use during pregnancy,” the obstetrician warned my co-author, Natalia Emanuel, as she wrote a prescription for inhaled corticosteroids ...

Integration of real-world practice: By integrating real-world practice with clinical trials, PFs within randomized controlled trial bridge the gap between research and clinical care. This integration ...

Introduction In cluster randomised trials (CRT), groups (rather than individuals) are randomised to intervention and control conditions. Since the publication of the Ottawa Statement on the Ethical ...