Clear cell odontogenic carcinoma (CCOC) is a rare malignant neoplasm of odontogenic origin that predominantly affects the jawbones, particularly the mandible. Typically presenting in middle-aged to ...
Gynecologic clear cell cancers are aggressive malignant neoplasms with low response rates to chemotherapy. Among patients with advanced clear cell ovarian and endometrial cancers who received ...
Casdatifan, an HIF-2α inhibitor, showed a 33% objective response rate in ccRCC patients at a 100 mg daily dose. The drug targets hypoxia-inducible factor-2 alpha to disrupt tumor-promoting mechanisms ...
Clear cell sarcoma of the kidney (CCSK) is a rare paediatric renal malignancy predominantly affecting infants and young children. Distinct from other renal tumours, CCSK exhibits unique genetic and ...
CAR T-cell therapy is being adapted for clear cell renal cell carcinoma, targeting CAIX and CD70 to improve efficacy and safety. Early trials like COBALT-RCC and TRAVERSE show promising disease ...
Select patients with oligometastatic ccRCC might be managed with a period of metastasis-directed therapy alone. Serial metastasis-directed radiation therapy may delay systemic therapy in clear cell ...
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