The New England Journal of Medicine

Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery

Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we ...
Nature

Chromosomal effects of adeno-associated virus vector integration

Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Trials Database); however, little is known about the ...
Business Wire

InterSystems and IPA’s Subsidiary BioStrand Collaborate to Unveil the Innovative Integration of Vector Search with LENS ai for AI-Driven Healthcare Applications

VICTORIA, British Columbia--(BUSINESS WIRE)--IPA (IMMUNOPRECISE ANTIBODIES LTD.) (the “Company” or “IPA”) (NASDAQ: IPA), InterSystems, a creative data technology provider dedicated to helping ...
Nature

Differences in vector-genome processing and illegitimate integration of non-integrating lentiviral vectors

A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...
USA Today

Zhongqi Zhu Addresses Key Challenges in Vector Database and AI Technology Integration

A study on vector database and AI integration identifies unstable indexing, weak cross-modal fusion, and rigid resource scheduling as key barriers. By introducing HNSW optimization, unified feature ...