Ganji M et al., and Fudenberg G et al., postulated that the SMC family of ATPases, such as condensin and cohesion, extrude DNA into large loops. Energy from ATP hydrolysis helps the SMC proteins to ...

A living cell is able to neatly package a big jumble of DNA into chromosomes while preparing for cell division. For over a century, scientists have been puzzled for decades on how the process works.

How does a meter-long strand of DNA fit inside a cell without forming a tangled mess? This accomplishment comes courtesy of structural maintenance of chromosomes (SMC) proteins, which orchestrate the ...

It is one of the mysteries in biology: how does a cell neatly distribute its replicated DNA between two daughter cells? Scientists are split into two camps: the first argues that condensing works like ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

Researchers recorded the folding dynamics of the human genome over time, creating a novel 4-D map of genome organization. Simulation of DNA organized into two globules by loop extrusion. The figure-8 ...

A team of Chinese scientists has uncovered a hidden 3D structure in rice DNA that allows the crop to grow more grain while using less nitrogen fertilizer. The finding, published in Nature Genetics by ...

DNA loop extrusion is a method used to analyze how DNA is compacted into the nucleus whilst bringing regulatory elements close to protein coding genes. DNA, or deoxyribonucleic acid, is the genetic ...