These findings suggest complement protein levels may be an important biomarker for type 1 diabetes. Disruption of the complement system appears to precede the onset of islet autoimmunity (IA), making ...

C3G and IC-MPGN can be difficult to diagnose because they are so rare and their symptoms are vague and nonspecific. A kidney biopsy is considered the gold standard and usually needed to confirm the ...

An interferon-stimulated genes signature including IFI27 and OAS1, together with complement levels, may reflect the immune state of patients with SLE and identify active disease. An automated ...

Some patients with SLE and low-grade proteinuria may have early active lupus nephritis. Current systemic lupus erythematosus (SLE) guidelines recommend performing a kidney biopsy in patients with a ...

Medically reviewed by Jamin Brahmbhatt, MD Key Takeaways Complement 3 glomerulopathy (C3G) is diagnosed with a combination of ...