Mast cell leukemia (MCL) is a quick-progressing condition that leads to the buildup of mast cells in your bone marrow and other tissues. It falls into a group of diseases collectively known as ...

Mast cells develop from hematopoietic progenitors in response to stem-cell factor (KIT ligand), which is the ligand of the CD117 transmembrane tyrosine kinase receptor, encoded by KIT. CD117 regulates ...

Mast cell sarcoma is a rare, aggressive neoplasm composed of cytologically malignant mast cells presenting as a solitary mass. Previous descriptions of mast cell sarcoma have been limited to single ...

Mast cell activation syndrome, or disease (MCAS), is a condition that causes mast cells to release these substances too frequently, resulting in severe allergic reactions. After detecting an allergen, ...

Mast cell secretory granules are lysosome-like organelles that contain a large panel of preformed bioactive constituents, including lysosomal hydrolases, amines, cytokines, proteases and proteoglycans ...

Recent research has shown that the uterus has an abundance of mast cells in the gravid state and that and mast cell density is significantly higher in the uterus of pregnant compared with nonpregnant ...

Mast cell activation syndrome is a condition that causes mast cells to release an inappropriate amount of chemicals into your body. This causes allergy symptoms and a wide range of other symptoms.