Communication between oocytes and granulosa cells is essential for oocyte formation, dormancy, reawakening, and maturation. Researchers have demonstrated that a protein complex called the exocyst ...

A picture of a mouse MII stage eggs with the location of chromosomes (green) and the distribution of the histone modification H3K4me3 (purple). The team confirmed that H3K4me3 was significantly ...

Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...

The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these ...

Melina Schuh has been fascinated with ovarian germ cells, or oocytes, since she began her graduate studies in 2004. “[I] realized that only little was known about these important cells that are ...

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without ...