Ahead of the matchup, the Seahawks are favored to win by 7 points. They’ve had the week off and enjoy home-field advantage, while the 49ers have traveled from West to East and back in under two weeks with a depleted roster.

Chicago Bears and San Francisco have clinched postseason berths, but their Week 17 showdown will still carry big playoff implications for both.

The San Francisco 49ers had a dreadful defensive showing, but they got a stop when it mattered while their offense continued rolling.

The regular season has come to an end for the 2025 Chicago Bears, and though they have more football in front of them, it could have been a better game to enter the postseason on. The Bears fell to the Detroit Lions 19-16 to finish the regular season 11-6 atop the NFC North.

Purdy found Jauan Jennings for a 38-yard touchdown reception with 2:15 to spare for the 49ers’ much-needed yet seemingly ludicrous seventh touchdown of the night. He threw three touchdown passes and 303 yards, and also ran for two scores to help offset his opening-throw pick-six en route to a sixth straight win.

Seattle Seahawks quarterback Sam Darnold rips a pass over the middle to wide receiver Jaxon Smith-Njigba who makes an unbelievable adjustment in mid air to haul in the 19-yard catch in Week 18 against the San Francisco 49ers.

Stay up to date here with the latest news and highlights from the Indianapolis Colts' Week 16 matchup on Monday Night Football against the San Francisco 49ers.

The 49ers had a shot at the No. 1 seed in the conference and a bye for the wild-card round. San Francisco lost to the Seattle Seahawks in Week 18, and 49ers secured the No. 5 seed in the NFC in defeat. Outside of the season-ending loss, San Francisco had won its last six games.