Waking up to pee once every night is normal. Anything more than that may be nocturia.
There’s actually a term for getting up to pee in the middle of the night: nocturia. Most people will experience more nocturia as they age, because older bodies create less antidiuretic hormone (ADH), ...
VANCOUVER—Desmopressin treatment appears to reduce nocturia and other lower urinary tract symptoms while also significantly increasing testosterone levels in men with late-onset hypogonadism. These ...