It's the San Francisco 49ers vs Indianapolis Colts on Monday Night Football in Week 16 of the 2025 NFL season. Here's how to ...
Stick with CNN Sports all afternoon and evening as we provide live updates and analysis from both games, starting with the 4:30 p.m. ET kick off of Rams-Panthers.
There are only three certainties in life—death, taxes and Luke Kuechly knowing where a football is going. ESPN—during last night's prime-time matchup between the San Francisco 49ers and Indianapolis ...
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