The prior diagnosis of fatal astrocytoma in a 60-year-old man with Crohn's disease treated with natalizumab, a monoclonal antibody against α 4 integrins, was reclassified as JC virus–related ...

A 60-year-old man diagnosed with mantle cell lymphoma received an autologous SCT in first complete remission (CR) after three different regimens of chemotherapy. The conditioning regimen consisted of ...

Over the next month, the weakness progressed to flaccid paralysis of the right arm and the patient had a seizure. Repeat MRIs showed progression of confluent hyperintense white-matter lesions ...

February 19, 2009 — Three deaths from progressive multifocal leukoencephalopathy (PML) and a possible fourth case have been reported in patients taking the immunosuppressant drug efalizumab (Raptiva, ...

The Brief Reports on natalizumab were referred to Biogen Idec, the manufacturer, which offers the following response: After learning of one confirmed and one suspected case of progressive multifocal ...

We read with interest the article by Kharfan-Dabaja et al. 1 on two cases of fatal progressive multifocal leukoencephalopathy (PML) that developed after SCT. We report on a patient who developed this ...

Please provide your email address to receive an email when new articles are posted on . Use of a genetic risk test for patients considering immunosuppressive therapies associated with development of ...

A 34 year-old HIV positive man had declined anti-viral treatment. Over the course of 3 weeks, he developed progressive ataxia affecting the left side. Progressive Multifocal Leukoencephalopathy (PML): ...

New research has confirmed a strong link between four genetic mutations and progressive multifocal leukoencephalopathy (PML), a rare but often fatal brain infection that can be triggered by dozens of ...

A 55-year-old right-handed man with no past medical history presented with a two week history of headache and progressive aphasia. He was found to be HIV positive, with HIV-1 RNA PCR showing 293,000 ...