LA JOLLA, CA—Scientists at Scripps Research have developed a set of methods for the closer study of one of the least-accessible, least-understood players in biology: protein-sugar conjugates called ...

Proteoglycans—molecules consisting of a core protein with multiple sugar chains—are so complex that researchers usually study the protein and sugar components separately, which makes it difficult to ...

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin. These proteoglycans ...

The intricate interplay between heparan sulfate and the extracellular matrix is fundamental to tissue development, repair and disease modulation. Heparan sulfate, a complex glycosaminoglycan attached ...

In a recent study published in IScience, a team of researchers from the United States examined the impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways ...