Repatha (evolocumab) is a prescription injection that lowers low-density lipoprotein (LDL) cholesterol and reduces the risk of heart attack, stroke, and the need for heart surgery in adults with ...

You can inject Repatha into the abdomen, thigh, or upper arm. It’s injected subcutaneously (under the skin). If you’re injecting it into your upper arm, you may need a family member or caregiver to ...

Only inject Repatha (evolocumab) on its scheduled day. Do not inject a dose in advance. The timing of your Repatha dose on an injection day isn’t important, so you can adjust it as needed on that day.

Repatha was first approved in 2015 and has since been used by more than 8 million patients globally. 5,6 In August 2025, the U.S. Food and Drug Administration broadened the approved use of Repatha to ...