Transgene Publishes Phase I Data Supporting TG4050’s Potential in Preventing Head and Neck Cancer Relapse

TG4050 elicits strong polyepitopic, polyclonal, durable cytotoxic and effector neoantigen-specific CD8 T cell responses Results reinforce TG4050 ...
Business Wire

Transgene and PersonGen Announce Collaboration to Evaluate a New Combination Therapy Against Solid Tumors

STRASBOURG, France & SUZHOU, China--(BUSINESS WIRE)--Regulatory News: Transgene (Euronext Paris: TNG) (Paris:TNG), a biotech company that designs and develops virus-based immunotherapeutics against ...
Business Wire

Transgene Announces New Leadership Structure to Accelerate the Development of its Innovative Immunotherapy Portfolio

STRASBOURG, France--(BUSINESS WIRE)--Regulatory News: Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapeutics against cancer, announced that the ...
Nature

Transgene-specific host responses in cutaneous gene therapy: the role of cells expressing the transgene

A major issue in long-term gene therapy is host immune responses to therapeutic cells when transgene encodes a potential antigen. The nature of these responses depends on several factors including the ...
The American Journal of Managed Care

Case Report of Patient Death Following High-Dose Gene Therapy for DMD

In this case study, a patient who had Duchenne muscular dystrophy (DMD) and received high-dose transgene therapy to upregulate cortical dystrophin subsequently developed acute respiratory distress ...
Healio

First patient dosed in trial of dual-transgene intravitreal gene therapy for wet AMD

Please provide your email address to receive an email when new articles are posted on . The first patient has been dosed in a phase 1/2 clinical trial investigating 4D-150 for the treatment of wet age ...
Morningstar

Neurogene Announces Peer-Reviewed Publication Demonstrating Gene Therapy Candidate NGN-401 with EXACT™ Technology Regulates Transgene Expression in Preclinical Models of Rett ...

Neurogene Inc. (Nasdaq: NGNE), a clinical-stage company founded to bring life-changing genetic medicines to patients and families affected by rare neurological diseases, today announced a ...
Nature

Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer

We previously showed that high and sustained transgene expression of antigenic proteins induced transgene-specific immune responses. In the present study, a detailed relationship between the level of ...
JSTOR Daily

Sustained Transgene Expression despite T Lymphocyte Responses in a Clinical Trial of rAAV1-AAT Gene Therapy

Alpha-1 antitrypsin (AAT) deficiency is well-suited as a target for human gene transfer. We performed a phase 1, open-label, doseescalation clinical trial of a recombinant adeno-associated virus (rAAV ...