Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we ...

In the past few years, with the availability of near-complete sequences for several vertebrate genomes, the targeting of retroviral DNA integration has been subjected to genomic analysis. These ...

A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...

The CHOP's research team findings support the hypothesis that rare AAV integration can contribute to human oncogenesis, which ...

Digital or vector modulation can provide increased spectral efficiency, higher data security, and higher quality communications. This comes at a cost of increased system complexity and a resultant ...