The increasing interest in Bayesian group sequential design is due to its potential to reinforce efficiency in clinical trials, shorten drug development time, and enhance the accuracy of statistical ...

The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.

Journal of the Royal Statistical Society. Series B (Statistical Methodology), Vol. 79, No. 5 (NOVEMBER 2017), pp. 1439-1462 (24 pages) We propose a Bayesian decision theoretic model of a fully ...

Bayesian inference provides a robust framework for combining prior knowledge with new evidence to update beliefs about uncertain quantities. In the context of statistical inverse problems, this ...