Randomized clinical trials serve as the standard for clinical research and have contributed immensely to advances in patient care. Nevertheless, several shortcomings of randomized clinical trials have ...

Pediatric clinical trials commonly experience recruitment challenges including limited number of patients and investigators, inclusion/exclusion criteria that further reduce the patient pool, and a ...

Knowledge Generated We present an overview of the rationale, trial types, key design elements and features, and practical considerations for commonly used biomarker-driven clinical trials. Examples of ...

Background: Clinical trials do not represent community settings,making widespread implementation of evidence-based medicineproblematic. New heart failure treatments are an example, asresults ...

Clinical trials that are embedded into usual care have the potential to yield outcomes of great relevance to the institutions where they are performed and at the same time to yield information that ...