377K views · 8.3K reactions | Feeling down?  Exercise can be your brain's best friend! 易 Boost BDNF levels and fight depression naturally!  #MentalHealth #BrainHealth #Exercise #WellnessJourney #DrLewisClarke #BDNF #Fitness #HealthyLiving #Endorphins | Lewis K. Clarke MD, PhD | Facebook
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FacebookLewis K. Clarke MD, PhD
377K views · 8.3K reactions | Feeling down?  Exercise can be your brain's best friend! 易 Boost BDNF levels and fight depression naturally!  #MentalHealth #BrainHealth
Lewis K. Clarke MD, PhD. . Feeling down? 😔 Exercise can be your brain's best friend! 🧠 Boost BDNF levels and fight depression naturally! 💪 #MentalHealth #BrainHealth #Exercise #WellnessJourney #DrLewisClarke #BDNF #Fitness #HealthyLiving #Endorphins
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#Brain-derived neurotrophic factor BDNF and Depression
What are “hope molecules” ? They’re myokines such as: • BDNF (Brain-Derived Neurotrophic Factor) – supports brain repair, neuroplasticity, mood elevation • Irisin – linked to reduced depression and improved metabolic health • IL-6 (in its exercise-released form) – reduces inflammation and helps energy balance • Myonectin, Myostatin, Cathepsin B, and others involved in mood, metabolism, and stress resilience These molecules cross the blood–brain barrier and signal the brain to create new neurons,
What are “hope molecules” ? They’re myokines such as: • BDNF (Brain-Derived Neurotrophic Factor) – supports brain repair, neuroplasticity, mood elevation • Irisin – linked to reduced depression and improved metabolic health • IL-6 (in its exercise-released form) – reduces inflammation and helps energy balance • Myonectin, Myostatin, Cathepsin B, and others involved in mood, metabolism, and stress resilience These molecules cross the blood–brain barrier and signal the brain to create new neurons,
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Regardless of whether someone uses talk therapy or pharmacology, or a combination of the two to achieve relief from depression, ultimately, any relief they experience is the consequence of neural plasticity (also called neuroplasticity), which is essentially changes in the function of neural circuits in the brain and/or body. Brain-derived neurotrophic factor (BDNF) was discovered for its role in promoting the growth, survival, and neuroplasticity of neurons, although it has other roles as well.
Regardless of whether someone uses talk therapy or pharmacology, or a combination of the two to achieve relief from depression, ultimately, any relief they experience is the consequence of neural plasticity (also called neuroplasticity), which is essentially changes in the function of neural circuits in the brain and/or body. Brain-derived neurotrophic factor (BDNF) was discovered for its role in promoting the growth, survival, and neuroplasticity of neurons, although it has other roles as well.
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