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Imine
Michael
Addition
Preparation
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Borohydride
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Organic Chemistry
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Making
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SOLVED:One problem with reductive amination as a method of amine synthesis is that by-products are sometimes obtained. For example, reductive amination of benzaldehyde with methylamine leads to a mixture of N -methylbenzylamine and N -methyldibenzylamine. How do you suppose the tertiary amine by-product is formed? Propose a mechanism.
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SOLVED: H3CH3CNHShow how this amine could have been synthesized by reductive amination of an appropriate aldehyde or ketoneYou do not have to consider stereochemistry: Draw both reactants. If there is more than one combination; draw only one. Draw one structure per sketcher: Add additional sketchers using the drop-down menu in the bottom right corner: Separate structures with signs from the drop-down menu:
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