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What are the differences between internal receptors and cell-surface receptors? a. Internal receptors bind to ligands that are hydrophobic and the ligand-receptor complex directly enters the nucleus, initiating transcription and translation. Cell surface receptors bind to hydrophilic ligands and initiate a signaling cascade that indirectly influences the making of a functional protein. b. Internal receptors bind to ligands that are hydrophilic and ligand-receptor complex directly enters the nucl
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